Your heart and Nitric Oxide

In 1998 three Americans (Robert F. Furchgott, PhD, Louis J. Ignarro, PhD, and Ferid Murad, MD, PhD) were awarded the Nobel Prize for their independent discoveries concerning "nitric oxide" as a signaling molecule in the cardiovascular system.
A signaling molecule is one which produces another substance, called a second messenger. Second messengers help in some way to carry a message from the outside of the cell to the inside. When Nitric Oxide, the signaling molecule, enters a cell, it activates an enzyme called guanylate cyclase, which produces cyclic GMP, the second messenger.

It's cyclic GMP that actually does the work of relaxing and dilating the blood vessels. In addition to relaxing and dilating blood vessels, Nitric Oxide functions to prevent heart disease and strokes in several additional ways. It helps prevent atherosclerosis by preventing platelets and white blood cells from sticking to the vessel wall. Nitric Oxide also, under many conditions, reduces the production of free radicals, which can cause your vessels to age rapidly, yet under other conditions may also increase free radical attack, so on balance it's wise to take a nitric oxide producing supplement that's combined with antioxidants. Further, it suppresses abnormal growth of vascular muscle cells which causes thickening of the vessels.


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What is the link between a healthy cardiovascular system and great sex?

Apart from the obvious, they both depend on a volatile and short-lived little molecule called Nitric oxide (NO).

Once regarded as little more than a toxic by-product of car exhausts, Nitric Oxide has been thrust onto the main stage of medical research in the last ten years. The discovery of its function is possibly one of the most important in the history of cardiovascular medicine.

Sex and Nitric Oxide

Possibly the most famous drug in the world, ViagraŽ was initially developed to treat heart disease. The story began in 1985 when two scientists at Pfizer wrote a proposal to find new drugs for the treatment of high blood pressure and angina.

Viagra works because part of the physiological process of erection involves the release of nitric oxide (NO) in the corpus cavernosum. This then activates the enzyme guanylate cyclase which results in increased levels of cyclic guanosine monophosphate (cGMP), leading to smooth muscle relaxation in the corpus cavernosum, resulting in increased inflow of blood and an erection.


ViagraŽ - is a registered trademark of Pfizer Inc.

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